Tag Archives: eternal

Running slows ageing

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New York: Scientists at the Stanford University Medical Center have found that jogging can slow down the ageing process.

In a study that lasted two decades they found that elderly joggers were half as likely to die prematurely from conditions like cancer than non-runners.

They also enjoyed a healthier life with fewer disabilities, according to the study which is published in the Archives of Internal Medicine.

The work tracked 500 older runners for more than 20 years, comparing them to a similar group of non-runners. All were in their 50s at the start of the study.

Nineteen years into the study, 34% of the non-runners had died compared to only 15% of the runners.

Both groups became more disabled with age, but for the runners the onset of disability started later – an average of 16 years later.

The health gap between the runners and non-runners continued to widen even as the subjects entered their ninth decade of life.

Running not only appeared to slow the rate of heart and artery related deaths, but was also associated with fewer early deaths from cancer, neurological disease, infections and other causes.

And there was no evidence that runners were more likely to suffer osteoarthritis or need total knee replacements than non-runners – something scientists have feared.

At the beginning of the study, the runners ran for about four hours a week on average. After 21 years, their weekly running time had reduced to around 76 minutes, but they were still seeing health benefits from taking regular exercise.

Lead author Professor James Fries, emeritus professor of medicine at Stanford, said: “The study has a very pro-exercise message. If you had to pick one thing to make people healthier as they age, it would be aerobic exercise.

“The health benefits of exercise are greater than we thought.”

Why calorie restriction prolongs life

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Chicago: Scientists have already proven that calorie restriction – but not nutrients – can prolong the lives of everything from yeast to mice and monkeys, but they didn’t know why, until now.

In a new study published in Cell magazine, US researchers suggest that the link between food restriction and longevity may be a molecular response to the stress from cutting back calories.

That reaction preserves critical cellular functions, helping the body to fight off age-related diseases.

In laboratory experiments on human cells, investigators found that cutting calories, while preserving the nutrients they need, starts a chain reaction in the mitochondria – or power houses of the cell – that results in the build-up of a coenzyme called NAD (Nicotinamide adenine dinucleotide).

This in turn amps up the activity of enzymes created by two genes called SIRT3 and SIRT4. The effect of all this is to strengthen the mitochondria, increase energy output and slow down the cell’s ageing process.

David Sinclair, a molecular biologist at Harvard Medical School who worked on the study commented: “We’re not sure yet what particular mechanism is activated by these increased levels of NAD, and as a result SIRT3 and SIRT4.

“But we do see that normal cell-suicide programs are noticeably attenuated,” he said, referring to the way cells are programmed to die as part of the aging and regeneration process.

“This is the first time that SIRT3 and SIRT4 have been linked to cell survival,” he said.

The fortification of the mitochondria in response to the stress of a much lower-calorie diet can help ward off diseases associated with ageing.

Damaged or dysfunctional mitochondria have been implicated in Alzheimer’s, stroke, heart disease and diabetes. It is thought that the common link is oxidative stress which damages the mitochondrial DNA leading to cell death.

Even given the growing recognition about the importance of the mitochondria in sustaining health, the researchers were surprised to find just how critical the so-called “battery packs” are to the life of the cell.

Specifically, they found that even when all the other energy sources in the cell, including the nucleus, are wiped out, the cell remains alive if the mitochondria are kept intact and functional.

“Mitochondria are guardians of cell survival,” said Sinclair. “If we can keep boosting levels of NAD in the mitochondria, which in turn stimulates buckets of SIRT3 and SIRT4, then for a period of time the cell really needs nothing else.”

Sinclair said the genes could be promising drug targets for diseases associated with ageing.